AMPK AGONISTS AMELIORATE SODIUM AND FLUID TRANSPORT AND INFLAMMATION IN CYSTIC FIBROSIS AIRWAY EPITHELIAL CELLS

The metabolic sensor AMP-activated kinase (AMPK) inhibits both the cystic fibrosis (CF) transmembrane conductance regulator (CFTR) Cl(-) channel and epithelial Na(+) channel (ENaC), and may inhibit secretion of proinflammatory cytokines in epithelia. Here we have tested in primary polarized CF and non-CF human bronchial epithelial (HBE) cells the effects of AMPK activators, metformin and 5-aminoimidazole-4-carboxamide-1-beta-D-riboside [...]

By |2017-05-21T03:21:06+00:00enero 31st, 2013|Cystic fibrosis, Documentos científicos|Comentarios desactivados en AMPK AGONISTS AMELIORATE SODIUM AND FLUID TRANSPORT AND INFLAMMATION IN CYSTIC FIBROSIS AIRWAY EPITHELIAL CELLS

INHALED MANNITOL IMPROVES THE HYDRATION AND SURFACE PROPERTIES OF SPUTUM IN PATIENTS WITH CYSTIC FIBROSIS

The airway mucus in patients with cystic fibrosis (CF) is dehydrated and adhesive and accumulates in the airways, resulting in chronic inflammation, infection, and progressive loss of lung function. Inhaled mannitol improves mucus clearance and, when administered over 2 weeks, it improves lung function in CF (Jaques et al. Chest. 2008;133(6):1388-1396). The changes in the [...]

By |2017-05-21T03:21:25+00:00enero 31st, 2013|Cystic fibrosis, Documentos científicos|Comentarios desactivados en INHALED MANNITOL IMPROVES THE HYDRATION AND SURFACE PROPERTIES OF SPUTUM IN PATIENTS WITH CYSTIC FIBROSIS