1. Nine normal subjects (eight male, one female) on a fixed daily intake of 150 mmol of sodium and 80 mmol of potassium, were randomized to receive either 3 days of 1.0 litre total water intake/24 h (food + fluid) or 4 days of 6.8 litres total water intake/24 h, and were then crossed over [...]
The tubular handling of sodium in two groups of healthy old people, under the action of indomethacin and aldosterone was studied. Urinary aldosterone elimination was measured. From the results obtained, it is deduced that the elderly lose sodium through incompetence of the distal nephron. The possibility is put forward of a Na-K-ATPase deficit and/or interstitial [...]
No abstract available.
We examined osmotic control of thirst and free water clearance in healthy older (65+, n = 10) and younger (Y, n = 6) subjects during a 3-h rehydration period after an approximately 2.4% decrease in body weight. Plasma volume (PV), plasma osmolality (Posm), renal function, and thirst were measured before and after dehydration and during [...]
This study examined the effects of hyperhydration on thermoregulatory responses during compensable exercise-heat stress. The general approach was to determine whether 1-h preexercise hyperhydration [29. 1 ml/kg lean body mass; with or without glycerol (1.2 g/kg lean body mass)] would improve sweating responses and reduce core temperature during exercise. During these experiments, the evaporative heat [...]
It has been reported that a host develops a marked fever under dehydrated conditions compared with normally hydrated conditions (11). The present study was carried out to investigate whether ANG II is involved in the enhancement seen in dehydrated rats of the fever induced by bacterial endotoxin. The results showed that intravenous injection of bacterial [...]
Dehydration is a common clinical syndrome associated with many illnesses and treatments in the elderly. Prior studies have shown diminished sensation of thirst during water deprivation. It is currently unclear whether age-related decreases in thirst perception impair the defense against a hyperosmolar challenge. To examine the impact of water ingestion during hyperosmolality, young and old [...]
No abstract available.
The purpose of this research is to ascertain nursing home (NH) staffs' perspectives of the problem of dehydration in NHs (skilled nursing facilities) and have them identify clinically practical interventions to ensure that NH residents consistently take adequate fluids. Four focus groups with 28 NH staff members in attendance are held in three NHs in [...]