BACKGROUND: Oligoanuric forms of postdiarrheal hemolytic uremic syndrome (D+ HUS) usually have more severe acute stage and higher risk of chronic sequelae than nonoligoanuric forms. During the diarrheal phase, gastrointestinal losses could lead to dehydration with pre-renal injury enhancing the risk of oligoanuric D+ HUS. Furthermore, it had been shown that intravenous volume expansion during [...]
The differential diagnosis of hyponatremia is often challenging because of its association with multiple underlying pathophysiological mechanisms, diseases, and treatment options. Several algorithms are available to guide the diagnostic approach to hyponatremia, but their diagnostic and clinical utility has never been evaluated. We aimed to assess in detail the diagnostic utility as well as the [...]
BACKGROUND: Secondary school students often do not drink sufficient quantities of water during the school day to prevent dehydration, promote learning and good health. The study aimed to measure the effect of health promotion and the free provision of cooled filtered water on the consumption of water and soft drinks. It also aimed to explore students' views of drinking water provision. METHODS: A study was conducted with three secondary schools in North Tyne side. [...]
INTRODUCTION: The relative frequencies of the causes of hypernatraemia in children after the neonatal period are unknown. Salt poisoning and osmoregulatory dysfunction are extremely rare and potentially fatal. In this retrospective 10-year study, the incidence, causes and differential biochemistry of hypernatraemia in children is examined. METHODS: Children with hypernatraemia (sodium ≥150 mmol/litre) aged >2 weeks [...]
Extracellular fluid expansion is common in hemodialysis patients. Aggressive fluid removal may lead to intradialytic complications. High dialysate sodium concentrations may lessen complications, but may increase extracellular volume. We hypothesized that decreasing plasma sodium concentration during dialysis will increase sodium removal and decrease extracellular volume. STUDY DESIGN: Pilot clinical trial. SETTING & PARTICIPANTS: 16 patients [...]
OBJECTIVE: The study tested whether a combined environmental and educational intervention solely promoting water consumption was effective in preventing overweight among children in elementary school. METHODS: The participants in this randomized, controlled cluster trial were second- and third-graders from 32 elementary schools in socially deprived areas of 2 German cities. Water fountains were installed and [...]
The present study was designed to examine factors that could facilitate or impede adherence to proper hydration. Forty volunteers (20 male, 20 female) were randomly assigned to one of two groups: Informed Group (n = 20) and Uninformed Group (n = 20). Bioelectrical impedance was used to measure intracellular (ICW) and extracellular (ECW) body water [...]
Many diseases have multifactorial origins. There is increasing evidence that mild dehydration plays a role in the development of various morbidities. In this review, effects of hydration status on acute and chronic diseases are depicted (excluding the acute effects of mild dehydration on exercise performance, wellness, cognitive function, and mental performance) and categorized according to [...]
It is difficult to describe hydration status and hydration extremes because fluid intakes and excretion patterns of free-living individuals are poorly documented and regulation of human water balance is complex and dynamic. This investigation provided reference values for euhydration (i.e.; body mass; daily fluid intake; serum osmolality; M +/- SD); it also compared urinary indices in initial morning samples and 24-hr collections. Five observations of 59 [...]
Levels of thirst and ad libitum drinking decrease with advancing age, making older people vulnerable to dehydration. This study investigated age-related changes in brain responses to thirst and drinking in healthy men. Thirst was induced with hypertonic infusions (3.1 ml/kg 0.51M NaCl) in young (Y) and older (O) subjects. Regional cerebral blood flow (rCBF) was measured with positron emission tomography (PET). Thirst activations were identified by correlating rCBF with thirst ratings. Average rCBF was measured from regions [...]