To explore whether elevated plasma glucose might progress to diabetes via a mechanism that involves plasma hypertonicity, we evaluated the independent and joint effects of these variables on diabetes risk. Community-dwelling older adults (70+years), who reported no previous diagnosis of diabetes and had glucose levels below 200 mg/dl in the 1992 Duke EPESE survey, were [...]
OBJECTIVES: To determine whether plasma hypertonicity might be a marker of early frailty, this study tested the associations between plasma hypertonicity, incident disability, and mortality in nondisabled older adults. DESIGN: Longitudinal, observational study. SETTING: Community-based. PARTICIPANTS: Older adults (> or =70), who reported no disability and gave blood in the 1992 Duke Established Populations for Epidemiologic Studies of the Elderly survey (n=705), [...]
The intact skin represents a barrier to the uncontrolled loss of water, proteins, and plasma components from the organism. Owing to its complex structure, the epidermal barrier with its major layer, the stratum corneum, is the rate-limiting unit for the penetration of exogenous substances through the skin. The epidermal barrier is not a static structure. [...]
Although much is known about the effects of changes in electrolyte and water balance on serum sodium concentration, the quantitative relationships between body composition and the concentration of sodium in serum have not been established. Also, no definitive study has been made of the correspondence between serum sodium concentration and total serum osmolarity. It is [...]
Dysphagia may predispose stroke patients toward undernutrition and hydration. These comorbidities increase patient risks for reduced functional outcome and short-term mortality. Despite this impact, available information on relationships among dysphagia, nutrition, and hydration status in acute stroke is limited and conflicted. This study evaluated nutrition and hydration status in ischemic stroke patients with versus without [...]
Evolution has provided an elaborate network of regulatory systems that stabilize body-fluid volume, temperature and composition. This stability insulates cells from an ambient hostile world and assures them the best possible conditions in which to function optimally. When one of these regulatory systems fails, cells and even whole organ systems cannot function properly. This paper [...]
Background and Aims: Fluid requirements of children vary as a function of gender and age. To our knowledge, there is very little literature on the hydration status of French children. We assessed the morning hydration status in a large sample of 529 French schoolchildren aged 9-11 years. Methods: Recruited children completed a questionnaire on fluid [...]
The chronology of hemoconcentration and hemodilution associated with changes in posture, and the reliability of venous hematocrit (Hct), hemoglobin (Hb), and plasma proteins (PP) as indicators in evaluating changes in plasma volume were determined in seven male subjects. Red cell mass was also measured by the CO method at the termination of the erect and supine positions. Movementto and from supine and erect positions produced consistent, rapid, and progressive changes in Hct, Hb, [...]
This study determined the fluid balance of elite female basketball players before and during competition. Before and during two international games seventeen national level players (age: 24.2 ± 3 y; height: 180.5 ± 6 cm; mass: 78.8 ± 8 kg) were assessed. Fluid balance assessment included pregame hydration level as determined by urine specific gravity [...]
Hydration and nutrition are essential for the maintenance of life. In patients at the end of life, artificial hydration and nutrition pose clinical, ethical, and logistical dilemmas. No strong evidence exists supporting the use of parenteral hydration/nutrition for the majority of terminally ill patients; however, a subset of patients may derive some benefit. Uncertainty about [...]