REDUCED THIRST AFTER WATER DEPRIVATION IN HEALTHY ELDERLY MEN

To determine whether responses to dehydration are altered with age, we investigated the thirst, fluid and electrolyte responses, and hormonal responses to 24 hours of water deprivation in seven healthy active elderly men (67 to 75 years old) and seven healthy young men (20 to 31 years old) who were matched for weight loss during [...]

By |2013-01-31T18:34:20+00:00enero 31st, 2013|Age and the elderly, Scientific papers|0 Comments

THIRST AND FLUID REGULATORY RESPONSES TO HYPERTONICITY IN OLDER ADULTS

To assess the fluid regulatory responses in aging adults, we measured thirst perception and osmoregulation during and after infusion of hypertonic NaCl) saline in older (72 +/- 2 yr, n = 6) and younger (26 +/- n = 6) subjects. Hypertonic saline was infused at 0.1 min-1.kg-1 for 120 min. On a separate day, the [...]

By |2013-01-31T18:34:20+00:00enero 31st, 2013|Age and the elderly, Scientific papers|0 Comments

MECHANISM OF ATTENUATED THIRST IN AGING: ROLE OF CENTRAL VOLUME RECEPTORS

To test the hypothesis that the inhibitory action of central blood volume expansion on thirst and renal fluid regulation is attenuated with aging, we monitored the drinking and renal responses of dehydrated older (70 +/- 2 yr, n = 6) and younger (24 +/- 1 yr, n = 6) subjects during 195 min of head-out [...]

By |2013-01-31T18:34:20+00:00enero 31st, 2013|Age and the elderly, Scientific papers|0 Comments

THE HYDRATION INFLUENCE ON THE RISK OF STROKE (THIRST) STUDY

OBJECTIVE: There is a decreased sensation of thirst and often dehydration among the elderly population. It is unclear whether it represents a contributing factor for cerebral ischemic events. DESIGN: Consecutive patients presenting to a University Hospital within 24 h of symptom onset, and a discharge diagnosis of acute ischemic stroke or transient ischemic attack in [...]

By |2013-01-31T18:34:19+00:00enero 31st, 2013|Age and the elderly, Scientific papers|0 Comments

COMBINED MODALITY THERAPY IN THE ELDERLY POPULATION

The incidence of cancer among older patients continues to rise. The use of combined modality therapy has improved survival in a variety of malignancies, including rectal, head and neck, and lung cancer; however, the addition of chemotherapy increases substantially the toxicities of treatment. Elderly patients have generally been excluded from prospective clinical trials and as [...]

By |2013-01-31T18:34:18+00:00enero 31st, 2013|Age and the elderly, Scientific papers|0 Comments

MECHANISMS OF RENAL TUBULAR DEFECTS IN OLD AGE

The mechanisms of renal tubular dysfunction in old age have been examined in twenty-eight clinically healthy elderly subjects without infection, and in fourteen subjects of similar age with laboratory evidence of intrarenal infection. The data were compared with those from thirteen clinically healthy young subjects. Studied were: proximal tubular (Tm(PAH)) and distal tubular (CH2O) activity, [...]

By |2013-01-31T18:34:05+00:00enero 31st, 2013|Age and the elderly, Scientific papers|0 Comments

THE RESPONSE OF ARGININE VASOPRESSIN TO INTRAVENOUS ETHANOL AND HYPERTONIC SALINE IN MAN: THE IMPACT OF AGING

The effect of age on the hypothalamic-hypophyseal-renal axis in normal man was determined by assaying plasma arginine vasopressin (AVP) responses to inhibitory and to secretory stimuli. Nine young (21-49 years) and 13 old (54-92 years) subjects received IV ethanol (375 mg/m2 per min). AVP levels fell progressively during the infusion in the young group, but [...]

By |2013-01-31T18:34:05+00:00enero 31st, 2013|Age and the elderly, Scientific papers|0 Comments