Background & aimsnNasogastric feeding may result in gastro-oesophageal reflux and, therefore, increase the risk of aspiration. This may be greater when feeds are administered via a bolus than by infusion. We aimed to measure gastric emptying time and quantify gastro-oesophageal reflux in healthy volunteers given a liquid feed via an oral bolus (OB), a nasogastric tube bolus (TB) and a nasogastric tube drip (TD).nnMethodsnTwelve male volunteers participated in three separate studies (OB, TB and TD) in random order, each 3days apart. The feed consisted of 220ml Ensure Plus (1.5kcal/ml), labelled with 12MBq 99mTc DTPA. The OB and TB were given over 5min and the infusion rate for the TD was 55ml/h. Gastric emptying time was measured using gamma scintigraphy. Gastro-oesophageal reflux was observed continuously until the stomach was empty, using a multichannel intraluminal impedance catheter.nnResultsnMean (95% CI) T50 gastric emptying times for the OB and TB studies were 41.3 (36.5–46.2)min and 36.2 (30.6–41.8)min respectively (p=0.19). The stomach emptied at a rate equal to the infusion rate in the TD studies. Median (IQR) number of reflux episodes for the OB, TB and TD studies were 4.5 (2.0–6.0), 3.0 (2.0–4.75) and 2.0 (0.25–6.25) respectively. Median (IQR) total duration of reflux for the OB, TB and TD studies were 38 (20–242), 49 (17–71) and 36 (1–125) s respectively (p=NS).