Exercise in the heat may predispose an athlete to an exertional heat illness. It is imperative to be knowledgeable on the influence of various nutritional supplements on exercise tolerance and hydration status. Because of the variety of nutritional ergogenic aids that are easily accessible to athletes, medical and health professionals must rely on empirical evidence when making conclusions about the efficacy of a supplement while not ignoring significant anecdotal reports that may resemble real-life situations more closely.