Scientific Papers
THE HISTORY OF 0.9% SALINE
BACKGROUND & AIMS: We aimed to trace the historical origins of 0.9% saline, how it came to be used so commonly today, and to consider whether its continued use can be justified. METHODS: We searched [...]
OSMOREGULATION, THE SECRETION OF ARGININE VASOPRESSIN AND ITS METABOLISM DURING PREGNANCY
This review stresses changes in osmoregulation as well as the secretion and metabolism of arginine vasopressin during pregnancy, focusing on human gestation. Pregnant women experience a decrease in body tonicity, plasma osmolality decreasing immediately after [...]
THIRST AND FLUID REGULATORY RESPONSES TO HYPERTONICITY IN OLDER ADULTS
To assess the fluid regulatory responses in aging adults, we measured thirst perception and osmoregulation during and after infusion of hypertonic NaCl) saline in older (72 +/- 2 yr, n = 6) and younger (26 [...]
THE TREATMENT OF HYPONATREMIA
Virtually all investigators now agree that self-induced water intoxication, symptomatic hospital-acquired hyponatremia, and hyponatremia associated with intracranial pathology are true emergencies that demand prompt and definitive intervention with hypertonic saline. A 4- to 6-mmol/L increase [...]