Following the discovery of the aquaporin-1 water channel over a decade ago, molecular techniques have been developed to examine the role of renal aquaporin water channels under numerous physiological and pathological conditions. The present article reviews current knowledge regarding the function and dysfunction of renal aquaporins in disorders of water metabolism. PMID: 15901245 [PubMed - [...]
Dehydration is responsible for the morbidity and, rarely, mortality secondary to vomiting and diarrhea from acute gastroenteritis. Despite the abundance of literature in the last 20 to 30 years focused on the treatment of dehydration with oral rehydration therapy, few studies have focused on the actual clinical diagnosis of dehydration. Conventional classification systems for assessing [...]
During exercise-heat stress, ad libitum drinking frequently fails to match sweat output, resulting in deleterious changes in hormonal, circulatory, thermoregulatory, and psychological status. This condition, known as voluntary dehydration, is largely based on perceived thirst. To examine the role of preexercise dehydration on thirst and drinking during exercise-heat stress, 10 healthy men (21 +/- 1 [...]
Disorders of body fluids are among the most commonly encountered problems in the practice of clinical medicine. This is in large part because many different disease states can potentially disrupt the finely balanced mechanisms that control the intake and output of water and solute. It therefore behoves clinicians treating such patients to have a good [...]
To evaluate the relative utility of clinical and laboratory parameters of dehydration in children for predicting the magnitude of percent less of body weight (PLBW), we studied 97 children who required intravenous fluids for acute dehydration. After a complete history and physical examination, the managing physician made a clinical estimation of dehydration for each child, [...]
BACKGROUND: Older adults are at increased risk of dehydration, yet water balance is understudied in this population. OBJECTIVE: This controlled diet study assessed the effect of age on water input, output, and balance in healthy adults. Hydration status (plasma osmolality and urine specific gravity) and body composition were also measured. DESIGN: Eleven men and 14 [...]
OBJECTIVE: To determine the validity and reliability of various clinical findings in the diagnosis of dehydration in children. DESIGN: Prospective cohort study. SETTING: An urban pediatric hospital emergency department. PARTICIPANTS: One hundred eighty-six children ranging in age from 1 month to 5 years old with diarrhea, vomiting, or poor oral fluid intake, either admitted or [...]
Dehydration is a frequent etiology of morbidity and mortality in elderly people. It causes the hospitalization of many patients and its outcome may be fatal. Indeed, dehydration is often linked to infection, and if it is overlooked, mortality may be over 50%. Older individuals have been shown to have a higher risk of developing dehydration [...]
No abstract available.