DEHYDRATION ENHANCES ENDOTOXIN FEVER BY INCREASED PRODUCTION OF ENDOGENOUS PYROGEN
The febrile responses in rats to an intravenous injection of the bacterial endotoxin Salmonella typhosa were investigated under normally hydrated and dehydrated conditions. When endotoxin was injected intravenously into the dehydrated rats, a biphasic-patterned fever resulted, whereas in normal rats an intravenous injection of endotoxin did not induce fever. No significant differences in febrile responses [...]