Various physiological mechanisms regulate sodium and water balance in the human body. These processes achieve acute and chronic sodium regulation and the simultaneous or sequential changes can be explained using a single physiological model. Steady intracellular water and osmolality is necessary for cell membrane integrity and cellular processes. Body fluids protect circulatory blood volume by [...]
The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a disorder of water balance characterized by hypotonic hyponatremia and impaired water excretion. The diagnosis of SIADH is based on the exclusion of other hyponatremic conditions, the presence of hyposmolality with inappropriate urine osmolality and a urine sodium concentration usually above 30 mEq/L. Some simple and [...]
BACKGROUND AND METHODS: Unusual water intake and drinking behaviour has occasionally been observed in individuals with Prader-Willi syndrome (PWS). The aim of this study is to explore whether this observation is a part of the PWS phenotype and what the consequences may be. The parents of 51 individuals with PWS (age range 2-40 years) were [...]
No abstract available.
The aim of the present study was to study salt and water metabolism in thyroid deficiency. We performed an oral water loading test (OWL) and a hypertonic 5% saline infusion test (HSI) in 16 patients with overt primary hypothyroidism before replacement treatment (PRE group) and after, in eight patients with subclinical hypothyroidism (SUB group) and [...]
During the bed-rest in the young subjects, the water intake should be depressed, because the diuretic is probably accelerated, and then the total body water and body weight is decreased by the water loss. In our previous study in 1991, we have reported that urinary volume was gradually increased, while water intake was decreased. Therefore, [...]
No abstract available.
Water metabolism is a major problem in infants of very low birth weight. Their surface is proportionally larger, they have a relatively low intracellular water volume and a high extracellular and total body volume. Kidney function is immature compared to bigger infants, and the neuroendocrine function is also immature. Finally the large surface and the [...]
No abstract available.
Due to its fundamental importance, the movement of water across cell membranes has been an active area of research for more than 100 years. This subject is central to consideration of normal water metabolism by terrestrial animals, as well as derangements in overall water balance that are frequently encountered by nephrologists in the care of [...]